M.J.
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Curriculum vitae

Miroslav Janosik

Current Position:  
Bio-Rad s.r.o. - Product Support for East Europe and Middle East
Quality Control and Clinical Diagnostics
 
Grant applications:
1997 - 1999
Participation in grant of GA CR 302/97/0476. Mutations in CBS gene: The effect to enzyme function in vitro and metabolism of S-AdoMet in vivo.

1999 - 2001 
Participation in grant of NIH, Fogarty foundation 2-020. Study of CBS gene in homocystinuria and arteriosclerosis.

2001 - 2002
Grant of GA Charles University 12/2001/C/1.LF. Properties of wild type and mutant CBS during folding and degradation.

2002 - 2004
Grant of GA Czech Republic (GAER 305/02/D167). The chaperones and stress factors effect on folding and stability of the wild type and mutant cystathionine beta-synthase.

2003 - 2008
Participation in grant of The Wellcome Trust International Senior Research Fellowship in Biomedical Science in Central Europe.

2004 - 2006
Participation in grant of GA Charles University 30/2004/C/1.LF. mRNA quality control: nonsense mediated decay and abnormal splicing in genes relating to homocysteine metabolism.


Memberships: 

2004 - present
Member of Czech Fobia - Czech Free & Open BioInformatic Association.

2004 - 2007
Member of European Society of Human Genetics (ESHG).

2003 - 2008
Member of Czech Society for Biochemistry and Molecular Biology.

2000 - present 
Volunteer of HUGO-MDI (Human Genome - Mutation Database Initiative).
Curator of CBS mutation database.

1995 - 1997 
President of LC IAESTE (The International Association for the Exchange of Students for Technical Experience) ICT Prague.

1995 - 1996  
Member of Academic senate of The Institute of Chemical technology Prague.

 

Education: 

1996 - 2001 
Charles University, 1st School of Medicine, Institute of Inherited Metabolic Disorders, Prague.
Ph.D. Molecular biology, genetics and virology.

1991 - 1996 
The Institute of Chemical Technology Prague, Faculty of Food and Biochemical Technology, Department of Biochemistry and Microbiology, Prague.
M.Sc. Chemistry and biochemistry.

1987 - 1991 
Chemical secondary school, Academy of Heyrovsky, Ostrava.
Analytical chemistry.

Work and Skills Summary:

 

2007 - present 
Bio-Rad s.r.o. - Product Support for East Europe and Middle East
Quality Control and Clinical Diagnostics (www.qcnet.cz; www.bio-rad.com)

2000 - 2007 
Charles University, 1st School of Medicine, Institute of Inherited Metabolic Disorders.
Research Associate. Eukaryotic expression; study of CBS folding, aggregation and ubiquitin-proteasome degradation pathway.
1998 - 2000 
Research Fellowships in laboratory of Prof. J.P. Kraus, University of Colorado, Health Sciences Center, Denver, USA.
Protein purification and crystallization; purification and characterization of mutant proteins.
1999 - 2000 
Curating  of the WWW CBS mutation database at http://www.uchsc.edu/cbs/.
1996 - 1998 
Charles University, 1st School of Medicine, Institute of Inherited Metabolic Disorders.
Ph.D. study. DNA sequencing and RNA analysis.
1993 - 1996 
Charles University, 1st School of Medicine Institute of Inherited Metabolic Disorders.
Research work - screening for mutations in Czech homocystinuric patients. Diploma thesis. 

Languages: 
Fluent in English (TOEFL exam in June 2000). Useful skills in German and Russian.

Computer skills:
Operating systems Windows 95/982000 and Unix.
Programs:  MS Office including MS Access (databases), graphical programs like PhotoShop, Corel, PaintShop or QuarkXpress and AdobeInDesign.
Internet technologies: WWW development and publishing. Programming skills including HTML, PHP, MySQL, JavaScript and CGI (Perl) languages.

Hobbies and Interests:
Jogging, mountain biking, travelling, computers and music.
 

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